Thing Thing 4 (Spoiler Warning)[]
Project 154 escapes from Vahl Dreig's containment room on a quest to find the person who made him into a bio-weapon, so he may get his revenge. On his way he runs into Project 153 who tries to kill him in an attack helicopter, but ultimately fails and is apparently killed when it crashes.
Nearly at his destination, Project 154 runs into Project Hades, one of the most powerful bio-weapons ever created. After defeating Hades, Project 154 moves into System Corps' main office, only to find the CEO is not present. The CEO appears on many screens and makes a long speech to 154 before removing his healing factor with a strange gas. 154 is then ambushed by countless waves of SystemsCorp employees, which he has no chance of stopping. When 154 apparently dies, you hear the CEO tell someone to get their buyers on the line because they have "worked out the kinks".

154 Fighting 153

154 looking at his Genetic Tube

154 Fighting Project Hades
List of weapons:
Pistols
Bren 10: Medium damage, high rate of fire
USP Tactical: low damage, very high rate of fire
CZ-75b: Low damage, high rate of fire
1911 A1: Medium damage, medium rate of fire
1911 Custom: medium damage, medium rate of fire
Magnums
Viper .44 Magnum: High damage, low rate of fire
Desert Eagle: Very high damage, low-medium rate of fire
SMG's
MAC-10: Low-medium damage, very high rate of fire
MP-5K: Average damage, medium rate of fire
Beretta 93r: Low damage, three round burst
Steyr TMP: Low damage, high rate of fire
Assault Rifles
Krinkov: Medium damage, fast rate of fire
HK-416: Low damage, fast rate of fire
Tavor: Low-medium damage, fast rate of fire
AK-47: Medium damage, medium rate of fire
XM-8: Low damage, fast rate of fire
Battle Rifles
HK-91 Description: High damage, medium rate of fire
SOCOM 16 Description: High damage, medium rate of fire
LMG's
HK-21: High damage, high rate of fire
Mini-Vulcan: Unusable by the player. Mounted on Project 153's helicopter.
Shotguns
Bernelli M4: High damage, medium rate of fire
USAS-12: High damage, three round burst
Pancor Jackhammer: High damage, high rate of fire
Special/Experimental
EX-41: High damage grenade launcher, low rate of fire, splash damage
GL-08 Flechette: Same as EX-41, but each grenade shoots piercing projectiles in all directions after detonating.
X-6 Flechette Rifle: High damage, High rate of fire, piercing projectile
Gauss Pistol: Medium Damage, high rate of fire, penetrating hitscan. Limited range; shots barely travel off-screen.
Gauss Shotgun: Very high damage 6-pellet spread, low rate of fire, penetrating hitscan. Limited range; shots barely travel off-screen. Not used by enemies. Picked up from Genetics Lab first armory.
XM-345 Skull Drill: One shot one kill, slow rate of fire, seeking projectile requires lock-on (cursor will turn red). Does not work against bosses. Not used by enemies. Picked up from Genetics Lab first armory.
Laser Cannon: Very high damage, low rate of fire, penetrating hitscan. Low range; shots barely travel off-screen. Not used by enemies. Picked up from Genetics Lab first armory.
Hades Rifle: Very high damage, Very low rate of fire, piercing projectile. Not used by other enemies. Picked up from Hades after defeating him.
N.U.K.E. : Kills all enemies within a wide radius (off-screen as well) with one shot. Infinite ammo, long reload time. The weapon fires an invisible range-limited (off-screen shots may not hit anything) hitscan, which must come in contact with an enemy or surface (wall, ground, etc.) to cause the deadly explosion. Not used by enemies. Requires all achievements (see Options -> Game Stats) to unlock in the Armory.